Biological Evolution in Interstellar Human Migration

by Paul Gilster on March 15, 2013

Centauri Dreams is happy to welcome Dr. Cameron M. Smith, a prehistorian at Portland State University’s Department of Anthropology in Portland, OR, with an essay that is the capstone of this week’s worldship theme. Dr. Smith began his career excavating million-year-old stone tools in Africa and today combines his archaeological interests with a consideration of human evolution and space colonization. He is applying this interest in his collaboration with the scientists at Icarus Interstellar’s Project Hyperion, a reference study for an interstellar craft capable of voyaging to a distant star. Recently Dr. Smith presented a paper at the NASA/DARPA ’100 Year Starship Study’ conference in Houston, Texas. His recent popular science publications in this field include “Starship Humanity” (Scientific American 2013) and the book Emigrating Beyond Earth: Human Adaptation and Space Colonization (Springer-Praxis, 2013). We can look forward to a follow-up article to this one in coming weeks.

by Cameron M. Smith

1. Interstellar Migration: An Insurance Policy for the genus Homo

Planets orbiting distant stars are now being discovered at a rapid pace, with hundreds known and countless worlds implied. As an anthropologist, I take a wide and long-term look at human evolution, and this development is very exciting to me; those almost unimaginably-distant planets are where humanity is headed, in the longer or shorter term. Humanity has been characterized by spreading itself wide across the Earth, and after first colonizing Mars we will surely wish to go farther, just as, in Polynesian legend, the siblings Ru and Hina—having explored the whole Pacific—chose to build a special vessel for a trip to the moon. Although civilization as practiced so far is perhaps its own worst enemy, I am optimistic that humanity’s better side will generally prevail, and that our species will invest in space colonization as an insurance policy for our lineage. Figure 1 indicates the five most recent mass-extinction events in Earth history, and Figure 2 indicates that even in recent times, civilizations have repeatedly collapsed and disintegrated, with no guarantee of recovery [click on figures to enlarge as needed]. In the larger picture, over long time, space migration is the best means of surviving such disasters.

cameron_smith_500

Recently humanity has spent just over a generation exploring the solar system just beyond our atmosphere, sometimes with robotic voyagers, and sometimes with our own bodies; for the past 23 continuous years human beings have already lived off of the surface of the Earth in various orbital stations; cosmonaut Sergei Krikalev has spent over 800 days in space, and his colleague Valeri Polyakov once remained continuously in orbit for well over a year. Despite some close calls, nobody has died in this nearly quarter-century of continuous space habitation, which has taught us some basics of space biology. Clearly, our species’ technical capacities are superb, and the essential technologies for long-term stays in space are being sketched out. We also have realistic destinations in view, and highly-focused, forward-thinking physicists and mathematicians working on how to reach those destinations with unique propulsion systems.

Will developing space technology be enough, however, to pave a way to space colonization? It will be part of the equation, but the equation is not complete. Space colonization will be about humans living off of Earth, but human biology off of Earth is only barely understood, and only in the cases of the individual physiology of adults, for short periods of the entire life course. Space colonization, however, will be about humans living out entire lifetimes—from fertilization to embryo development and so on through adulthood—and in populations (rather than just individuals) and populations over multiple generations, not short stints in Earth orbit. For these reasons, at least, we need an anthropology of human space colonization. Anthropology studies the biocultural evolution of our lineage and some of our closest relatives. In this article I would like to introduce some of the biological issues involved in space migration, specifically among multigenerational, interstellar voyages. In a second article I will introduce cultural evolution in such vessels.

cameron_smith_2_500

2. Where to Begin?

Space colonization will be a continuation of human evolution. I don’t mean this in the shallow sense of a ‘March of Progress’, but in a deeper, more mature and more useful way. Humans are life forms, and thus we change through time, both biologically and culturally. When such change allows us to live in new places—for example, the Canadian Arctic (over 5,000 years ago), the islands of the Pacific (over 3,000 years ago), or Earth orbit—it is called adaptation. Space colonization, then, will be an attempt at adaptation, and if we want to succeed in this adaptive endeavor we should be informed with everything we know about evolution in general and adaptation in particular.

Generally speaking, while it is clear that humanity has adapted to many ecological niches over time, it is equally clear that our adaptation differs significantly from that of most other life forms. This is because humanity adapts more culturally and technologically than biologically; witness our essential biological similarity across the globe, despite a few regional variations in skin color, hair texture and so on. Rather than adapting largely by body, then, we adapt largely by mind, which generates complex behavior (such as adjusting our kinship rules and sex taboos to match our distribution across landscapes) and complex technologies (including everything from inventing sailing vessels and stellar navigation in the Pacific to walrus-hunting watercraft and harpoons in the Arctic) allowing our species to flourish in places never dreamed of by our earliest bipedal ancestors. Having said this, humanity continues to evolve biologically even today, and will continue beyond Earth, and that evolution must be considered.

While technology is a cultural invention, in this article I will leave the technologies of space colonization to the engineers, and focus on the biological issues involved in interstellar voyages. These have been sketched out before in disparate literature; here I would like to update the material and consider it specifically in the case of current draft studies of interstellar vessels.

3. A Thoughtscape for Planning Interstellar Voyages

Current plans for interstellar voyaging essentially envision a gargantuan starship hurtling on a one-way voyage from Earth towards a distant star system. Interstellar craft would have to be very large—perhaps kilometers on a side—to house populations in the thousands, as I will discuss below. The most distinctive characteristic of these colony ships is that they would essentially be closed systems, with no opportunity for bringing in new genes, maintenance or repair materials, or consumables, such as water or breathing gases. These ‘Space Arks’ would have to be regenerable and self-contained, a fascinating challenge not just in engineering but also concerning biology and culture.

Presuming that we could build such vessels, the main engineering challenge is going to be propulsion (an issue being tackled right now by the scientists at Icarus Interstellar). Our galaxy, the milky way, contains an average density of .004 stars per cubic light year, and the closest star to Earth, Proxima Centauri, is 4.2 light years away. At light speed that is 4.2 years of travel time, but today, attaining that speed (or, technically, something very close to it, as light speed is not thought to actually be attainable by anything other than individual photons or similar particles) is unrealistic. How fast can we go? The fastest humans have moved is about 24,790mph (just over .00003% the speed of light), on Apollo X in 1969. At that pace, Proxima Centauri is about 140,000 years away. Maybe we can do much better, though. In the last 150 years we have increased human travel speeds almost a thousandfold up from the locomotive’s 30mph (the Voyager spacecraft speed along at about 1,000 times the speed of a locomotive). If we can do something similar in the near future, travel times become significantly more manageable. A 100-fold increase in speed from Apollo X (bringing us to just under 3,000,000 miles per hour) would take us to Proxima Centauri in something under 1,400 years. This is getting manageable, but is still a long time; imagine launching the ship during the Dark Ages (just after the collapse of Rome, about 1,400 years ago) and having it arrive at its destination in the time of such oddities as desktop computers. If, however, we manage to make a 1,000-fold increase in speed (bringing us to about 30,000,000mph) in the next century or so, then the heavenly wonders of Proxima Centauri (actually we don’t know what it is like there, yet, but I am being optimistic) could be achieved in about 140 years (see Figure 3). This is a very manageable timescale, a distance only that from today’s world to that of 1872–less than five generations distant and essentially comprehensible.

This, then, is the thoughtscape I am exploring in this article; voyages on the order of under two centuries, carrying some thousands of people (a number discussed below) before reaching another solar system. What biological and cultural issues need to be addressed on such voyages? While the answer will be some time coming (I’m currently investigating it in research for my forthcoming textbook on the anthropology of space colonization), I can sketch out some below.

cameron_smith_3_500

4. The Biology of Interstellar Voyaging

While evolutionary biology is currently undergoing significant revision in the light of new genomic data, the principles of evolution are largely intact. These include the four main processes (genetic mutation, selection, migration and drift) that change the properties of the gene pool over time. Each is discussed below.

4.1 The Biology of Interstellar Voyaging: Mutation

Mutation is ultimate source of new variations, such as coarser hair, or darker skin than one’s fellows. In common speech a mutation is thought of as being deleterious, but scientifically speaking mutations could be advantageous, disadvantageous or neutral. Some mutation is a result of radiation, and interstellar voyage designs will have to consider trapped particles, radiation energy near Earth and constrained within the Van Allen belt (and presumably about other planets with analogs of the Van Allen belt; cosmic rays derived from many sources outside this region, and solar radiation blasts out of suns. Radiation can degrade biological tissues and cell functions, and it can also be a powerful mutagen, altering DNA; recently it has been suggested that cosmic radiation could increase the incidence of brain disorders.

Certainly radiation is an issue to be addressed, but it does not seem to be a showstopper for human space colonization. First, many shielding schemes have been devised. In interstellar craft some kind of radiation shielding will be necessary, but because shielding is heavy, designers will probably try to get away with as little as possible. How thin is too thin? This is difficult to answer; aside from clear cases of lethal exposure to high doses of radiation, its long-term effects are mysterious. One 1995 study tracked the health of over 70,000 children of parents who were within a kilometer of the nuclear bombings at Hiroshima and Nagasaki, Japan, during World War II. Surprisingly, there was no statistically significant difference between the study population and populations of children of non-irradiated parents, in terms of malignant tumors in early age, differences in sex of offspring, chromosomal abnormalities and other mutations. On the other hand, recent studies have shown highly elevated mutation rates in people living near the Chernobyl disaster site. We have plenty to learn.

The second reason that radiation will not be a deal-breaker for interstellar voyaging is that mutagenesis itself has recently been found not to be largely the result of such ‘one-off’ ‘zaps’ from space, but rather more the result of the failure of DNA-repair mechanisms on the molecular level itself (over 300 such mechanisms and processes have been identified in the human genome alone). Thus, DNA repair therapy will probably be a large part of mitigating radiation issues in interstellar voyages.

In short, anywhere beyond Earth’s natural radiation shielding, under which we have evolved for millions of years, the mutagenic environment will be new and therefore a candidate for affecting our genome. Obviously we will use technology to mitigate such effects, including shielding and management of DNA repair, but we must remember that we do not know everything and that it will take time to adjust—both biologically and culturally–to new environments.

4.2 The Biology of Interstellar Voyaging: Selection

Natural selection occurs when life forms are prevented from reproducing—or simply have less offspring than others of their generation—due to their genetic characteristics. For example, a fly born without wings is unlikely to have offspring, or at least less offspring than its cohort (because of its reduced health and reduced ability to find mates) such that ‘wingless’ genes are likely to be ‘selected out’. Concomitant to most ‘selection against’ certain characteristics is selection ‘for’ alternatives. It’s often thought that humanity has halted natural selection with modern medicine and technology, but this is an illusion; many people continue to die before giving birth because of their genetic properties, particularly in populations without access to modern health care; and several recent studies have shown natural selection to be underway in modern populations. Even so, by the time of interstellar travel health technology will be much advanced…and yet selection will continue, for at least three reasons.

First, conditions off of Earth will differ from the conditions on Earth, where a relatively narrow environmental envelope of temperatures, atmospheric pressures and elemental compositions, nutrient supply and gravity have prevailed. The conditions in interstellar craft might well approximate these conditions, but much experimental data indicates that even small alterations in such variables as breathing gas composition and pressure can negatively effect gene expression (the switching on and off of genes on very complex schedules) and development of vertebrate embryos during the critical phases of early formation (e.g. gastrulation). We will of course try to control such variables, but it is unlikely that we will be able to anticipate everything. It seems certain that there will be a degree of increased infant mortality as the human genome adjusts to new conditions in interstellar colony craft, however carefully we design them. I am currently researching the genetic aspects of human development and the life course in environments slightly different from those on Earth.

Second, selection will likely play out in the cases of sweeps of novel diseases through interstellar craft populations. Again, we will be very careful, but it is impossible to anticipate all biological change, and in smallish populations (e.g. the 10,000+ that I suggest for interstellar craft; see below) inhabiting closed environments, sweeps of new disease, I believe, might well occur. Whether such sweeps structure the interstellar craft genome structurally is impossible to know, but we must be prepared for this possibility.

Finally, most interstellar voyage plans head not for other stars per se, but for their planets, where the resources and landscapes of alien worlds will allow humans to once again take to a planetary surface. In such a case, it is certain that new environmental conditions will be encountered. We will use technology to mitigate environmental selection, of course, but we must remember that we are only just appreciating the significance of epigenetics, the throwing of genetic switches by environmental factors. How will new planetary conditions shape the human genome? We simply can’t say, but we can be sure that it will occur. For example, even the Apollo lunar walkers commented on the lunar soil they inadvertently tracked into their lunar modules; you can bet that they breathed it in. They stayed on the moon only for days…but what would be the effect of such close contact of the human body with new chemistries of different worlds over the course of a lifetime? What genetic switches could be activated in such conditions? We don’t and can’t know; we can estimate and model, but we can’t be certain, and it is likely that selection will occur on our genome again in new planetary environments, at least until we control it with technology.

To succeed in migrating from Earth we are going to have to accept some risk. We do this on a daily basis; in the U.S. many of us take a daily commuting gamble, with nearly a hundred losing that bet—dying in car crashes—daily. If we can take that risk, surely we can adjust to the return of a degree of selection in our dream to colonize space and supply our genus with an insurance policy against extinction or even ‘just’ civilization collapse.

Ultimately, natural selection can be strongly mitigated with technology and is unlikely to strongly structure our genome in the 140-year ‘thoughtscape’ I am currently exploring. But natural selection should not be discounted in plans for interstellar colonization, particularly because it will ultimately involve generations of humanity adapting to new environments.

4.3 The Biology of Interstellar Voyaging: Migration and Drift

Migration is the flow of genes into and out of gene pools (populations) and it is a major factor on Earth, where humans have vast travel networks and today mate even across different hemispheres of the globe. However, in interstellar voyaging craft populations will be relatively fixed (rather than expanding, until new planets are reached), and migration will be between rather small sub-populations of the interstellar craft, an issue returned to below.

Drift, on the other hand, is the result of chance events in the history of a species; a good example, and one most suitable here, is the founder effect in which the genetic composition of a population is strongly conditioned by its founding members. This factor will be of critical importance in interstellar colony voyages because they will be closed genetic systems—as just mentioned—whose genetic structure will be largely established by the founding populations.

Regarding populations, we should take a minute to consider the size of interstellar colony groups. Should we send tens, thousands, millions of people? One way to tackle this issue is to consider our species’ MVP or ‘minimum viable population’, the figure required to avoid the deleterious effects of inbreeding. This figure has been much debated; anthropologist John Moore has suggested a figure of about 150, while others have suggested closer to 500. Such small populations, however, are highly vulnerable to single catastrophes, and my own calculations have suggested an MVP of about 3,000, multiplied by a ‘safety factor’ of 4 to 6 for an interstellar colonization population ‘reference figure’ of 12,000-18,000, which I consider significantly capable of surviving both biological disasters such as disease sweeps and a number of significant technological failures, over the low-centuries figure to reach, for example, Proxima Centauri.

From 12,000 to 18,000 people, then, as a ballpark figure for a founding population for interstellar migration; how do we pick them from the human population? Evolutionary ecologists measure s species’ health by its genetic diversity because a diverse gene pool allows for adaptation to new, unexpected conditions; thus our colonists should be biologically diverse, representing the human genome worldwide (which includes variations adapted to low and high altitudes, for example). However, an over-inclusive approach could endanger future populations if certain genetic maladies are allowed among the founding population. The screening process—determining that certain humans should not and could not participate in off-Earth colonies—seems to go against the very Enlightenment values of equality and freedom at the heart of Western Civilization, but if we are going to succeed in human space colonization we cannot ignore genetics. This is nothing new: over thousands of years human cultures have already devised many and elaborate kinship systems and sexual regulations that prevent the genetic disorders associated with close inbreeding; a survey of Yale’s Human Resources Area Files ethnographic database indicates that most cultures ban marrying or mating between parents and siblings of parents, siblings themselves, grandparents, and first cousins. Humanity has been looking after our genome for a very long time.

The main issue in genetic screening is the detection of genetic disorders that might send a biological ‘time bomb’ into future populations, particularly small and closed populations. But even this ‘simple’ issue includes moral and practical hurdles. In practical terms, this is evident in a depressing poster generated by the federal Genomic Science Program, a rather gruesome document pointing out the location–on each of our chromosomes–of many hundreds of genetically-controlled disorders, from cancers to deafness (we should remember that genes don’t exist simply to cause problems, and that in most cases they build healthy individuals!). Screening for interstellar suitability here seems simple enough: people carrying certain genes would have to remain Earthbound. The significant complication, though, is that while many genetic disorders are known to be simply correlated with certain genes—these are called Mendelian traits—modern genetics finds that more disorders are not so easily ‘pinned’ onto just one easily-spotted genetic marker. Indeed, in a recent paper Professor Aravinda Chakravarti of the Johns Hopkins School of Medicine noted that the textbook concept of simple Mendelian inheritance—‘evolution basics’ that I teach in my own classes—seems to be melting away in light of his ‘genetic dissections’ of the real mechanisms of genetic disease, replaced by far more complex models. For example, many disorders are polygenic, the complex result of the interactions of many genes. And, single genes can be pleiotropic, affecting multiple characteristics of the individual organism! To further complicate matters, even though one might carry the gene or genes ‘for’ a certain disorder, environmental factors encountered during the course of life can determine whether or not those genes are activated in such a way as to ‘express’ the genetic disorder.

We must address such issues because, as geneticist David Altshuler of the Harvard Medical School recently noted in the New York Times, “Even if you know everything about genetics, prediction will remain probabilistic and not deterministic.”

And what if we could identify, say, a ‘gene’ for deafness? Just after thirty years of age, Beethoven became deaf; it this were due to a genetic disorder, should he have been ‘selected out’? Should Beethoven’s deafness have been ‘pre-emptively corrected’? He completed much fine music even after his deafness. And what about Stephen Hawking’s genetic disorder, amyotrophic lateral sclerosis? Would screening out someone carrying a certain likelihood of expressing that disorder be a good idea? We already make mate choices, some based on actual or perceived health and future of our partners, and even the fates of some of our embryos. For the health of off-Earth populations, we must be willing engage in these complex discussions to determine what levels of probability we are comfortable with in terms of deciding whether or not a given person can participate in space colonization. Philosophers of morality could be of great help in clarifying the issues in a secular way, and designing real-world solutions.

On the surface, we might think that a solution to these issues would be to encourage the breeding of a master ‘Space Race’, as in the science fiction film Gatacca. But this idea is counter to nature and all of population genetics. If all are identical, all are subject to the same evolutionary ‘sweep’–for example, a single devastating disease. This is why ecologists measure—as mentioned–the health of a species not by its sameness, but by its genetic diversity, which is a well of untapped variation that might provide for a changed future. Any ‘super-race’, then, would be genetically imperiled in the manner of the closely-inbred royal families of Europe, who, according to Dr. Alan Rushton, author of Royal Maladies: Inherited Diseases in the Royal Houses of Europe, have suffered statistically more than their share of genetic disorders.

All in all, from a genetic perspective we have plenty of both moral and genetic reasons to begin studying the genetics of space colonization today. And, critically, we will have to ensure the genetic health of our domesticates and symbionts as well: we will be taking many domesticated plant and animal species off of Earth, some as food, some as companions, some as providers of such things as fibers. A good way to proceed would be to set clear milestones for what we want to know before we can leave the Earth, and work towards meeting them; otherwise, the endless, question-generating process at the heart of science might keep us here too long–and it is only a matter of time before a civilization- or species-destroying event will occur again on Earth.

In the end, if we are going to migrate from the Earth we are going to have to grapple with the probabilistic world of the genome in order to make smart—and moral—choices about the genetic health of our descendants. Regarding the important issue of preserving genetic variability, this could be maintained by ensuing gene flow among sub-populations of the interstellar craft as well as such technological means as carrying along from Earth ‘novel’ genetic material in the form of stored sperm and egg, as well as artificial mutagenesis. All of these measures are under investigation.

5. The Biology of Interstellar Voyaging: Final Comments

Over the course of several generations, as on voyages to nearby stars with propulsion systems that are beginning to seem reasonable, interstellar voyaging is entirely possible from a genetic perspective, with two provisions. First, we will have to ensure the genetic health of the colonist population as it will be under strong founder effect. Gene therapies, carrying genes from Earth in the form of stored eggs and sperm, and even the artificial induction of mutations can all be used to mitigate such effects, but at some point it will cease to be desirable to keep ‘pushing’ a human Earth genome into interstellar space. This brings us to the second proviso, and that is that natural selection will in fact return as a significant concern in human evolution, particularly when the unknowns of new planetary environments are encountered (even if they are surveyed by reconnaissance vehicles first).

We should note that, in the currently-considered timelines and populations, according to what we know about human biology it is unlikely that humanity will undergo speciation in less than a few thousand years (Figure 1, lower right).

These lessons remind us that adaptation is a continual process of the adjustment of the genome to environmental conditions. In non-humans that evolve reactively, with no conscious effort, this equilibriating process is slow and uncentralized and results in many extinctions over time. In humanity, consciousness can be used to help proactively shape our evolution, but we must remember that the only way to stop evolution is by extinction. We should accept and learn from the fact that if things live, they evolve and adapt. We should plan our adaptation to space as students of evolution. We must internalize the truth that the nature of the universe is change, not fixity, and allow this truth to condition our plans for the human colonization of space.

In the next article I will address cultural evolution, and some issues in the coevolution of DNA and culture, in biocultural evolution.

tzf_img_post

ljk May 15, 2013 at 9:20

https://share.sandia.gov/news/resources/news_releases/brain_supercomputers/

NICE! the brain as a model for future supercomputers

ALBUQUERQUE, N.M. – The brain’s repute took a big hit in 1997 when an IBM supercomputer defeated world chess champion Gary Kasparov in a match reported around the world.

But in the second round, the brain is back.

A Sandia National Laboratories-supported workshop in Albuquerque called NICE, for Neuro-Inspired Computational Elements workshop, discussed ways to use the brain’s superior ability to send electrical signals along massively parallel channels, with multiple intersections at downstream nodes, to handle rapidly changing, high-volume information.

The hope is that rather than using the limited “if this, then that” logic of conventional computer architectures to absorb steadily increasing yet often incomplete data, cognitive systems will be able – like the brain – to learn, adapt, hypothesize, and then suggest answers.

As Julia Phillips, Sandia vice president and chief technology officer, put it in her opening talk, “Neuro-inspired computing is at the intersection of cognitive science and technology, nano devices, microsystems and computer and information sciences. It transcends our traditional approaches.”

It also happens to reside at the major crossroads of Sandia research areas, she pointed out.

Of course, conventional computer architectures still predominate and Moore’s Law isn’t dead yet – just “eroding,” as Sandia director of computing research Rob Leland told the workshop. But when it becomes impossible to shrink circuits any smaller, as it seems will be the case in the next 10 years – what’s next? And as the von Neumann/Turing architecture of the last 60 years staggers beneath the weight of uncertainties increasingly inherent in working with huge realms of fuzzy data, what then?

Workshop participants proposed using the configuration of the brain as a model. First, isolate the brain tissues that control aspects of behavior. Then analyze – microscopically and in very small time steps – the shape and behavior of the neurons sending the signals. Then duplicate that arrangement using conventional hardware and software, or most likely, a new solid-state substrate.

“National security challenges – Sandia’s main interest – have historically been addressed in the physical domain, which remains vitally important,” Leland said. “But these challenges today have intrinsically a cognitive aspect concerning the behavior of the individual and group, so just the physical realm isn’t going to be sufficient to address these issues. Our aspiration is to deepen our understanding of cognitive science so we can address these problems in the behavioral realms.” He listed possible domain intersections that included tissue-based and in-vivo sensors, optical nanosensors for chemical analysis within cells, regulated nanoassembly of circuits, digital antibodies and virus-sized logic chips.

Jim Olds from the Krasnow Institute at George Mason University went further in not only predicting the end of Moore’s Law but denying it ever had the importance the computing world assigned it. He presented what he called “the great stagnation argument: that Moore’s Law is not like the industrial revolution or electricity” because it produced few jobs and lately, no real economic growth.

A brain-inspired industrial revolution

“There’s been a slowed-down technological revolution, despite our feelings to the contrary,” he said. Because Facebook, “for all its enormous market capitalization,” and Google have few employees compared with Ford Motor Co., “it’s clear that technology from Moore’s Law isn’t translated into day-to-day lives. For some reason, we’re not seeing opportunities for getting ahead by hard work. It’s enabled us to enjoy leisure, and load movies onto iPads, but flying cars haven’t come to pass.”

To the contrary, he said, real median household income, which increased dramatically since the beginning of the 20th century, stopped increasing in the last 10 years. To solve this problem so “researchers are not sitting alone in their silos..we need a new, brain-inspired industrial revolution,” Olds said.

That might be found in the Obama administration’s recently announced project to map the neurons and network functions of the human brain. The $100 million project, which received a mixed reception from neuroscientists, will launch in 2014 and may continue for 10 years.

“This is a transformation from letting a million flowers bloom – from single PIs [principal investigators] to a major strategic investment,” Olds said.

“Brains are highly parallel, can reconfigure themselves dynamically in a few minutes and use molecular signal transduction [to pass messages],” he said. “In message-passing they use little power and finesse around bottlenecks [that would slow silicon] parallel computing systems.”

Apparently, though, the brain’s advantage isn’t speed. The brain uses wet-ware, Olds said, and is therefore slow compared to the speed of silicon chips, though more complex and therefore more powerful in many other ways.

A modest proposal

Slow signal speed didn’t faze Christof Koch, chief scientific officer of Allen Institute for Brain Science. “I have a modest proposal,” he told the group. “Imagine a 1-kilogram, three-dimensional block of silicon, or stacks of chips, all with 10 kilohertz clocks and each consuming microwatts of power. There’s much more silicon, and therefore it’s very expensive and heavy, like the brain! But, much less cost for heat sinks, much less air conditioning.”

The Allen Institute, he said, was founded in 2003 to support basic research in the brain sciences with a staff of 210, including 50 Ph.D.s.

“There are a thousand different cell types in the brain,” Koch said. “Every time we look at the brain, we see more and more complexities, like astronomers looking at the universe every ten years.”

The problems include science’s inability to simultaneously record more than 0.0001 percent of firing neurons, and, before the Obama proposal, “no central unifying projects. There are 10,000 labs with different questions, methods, protocols and standards, heading off exuberantly in all directions. Universities are not set up for large-scale systematic efforts.”

Jacob Vogelstein, a program manager at Johns Hopkins’ Applied Physics Laboratory, spoke about moving ideas into practical engineering. He described taking slices of mouse brain 2 to 3 millimeters on a side and 49 nanometers thick. “Line them up on top of each other and extract the [neuronal] network,” he said. Inputs and outputs can be simulated with Monte Carlo techniques that allow for randomness.

Is the brain really the right model?

Again, the difficulties could not be minimized. “In a tiny [brain] region, there are 25,000,000 synapses and cell bodies working through dendrites and axons,” Vogelstein said about the difficulties of creating a copy that might serve as a computing template.

Of course, there is always the question of whether the brain provides the right model, cautioned Mike Vahle, Sandia’s chief information officer. “Computer problems are taking characteristics that the brain seems particularly well-suited to handle,” he said. “But is pattern-matching the right paradigm? Is the technology attainable, are the ethical and cultural issues understood? Can we avoid the pitfalls that plague modern computers and networks: viruses, worms, hacking and computer security [problems in general]?”

Murat Okandan, who proposed and helped organize the workshop for Sandia, suggested the brain did indeed show the path for dealing with large, incomplete, noisy data sets. “First we’ll work with conventional CMOS devices and tools, with simulations of conventional system and architectures, and we’ll cross-pollinate. The ultimate goal would be to learn from the motifs we see in neural computation and instantiate that capability in a massively interconnected, self-reconfigurable substrate that natively does the computation. The question will always be, how much fidelity do you need to get the functionality you want?”

“It’s national reinvention: Time to lead again,” said Olds. He prophesized that the brain’s secrets, morphed into new computers, would “enhance the range of productivity to include retirement years; increase levels of safety and security so that normal decline of physical and mental abilities are lessened; improve method of wealth development leveraging Moore’s law. And help develop enhanced modeling of societies to keep life meaningful.

“To do that, we need to prime the pipeline with the right kind of folks: a transdisciplinary scientist that enhances ‘team science’ approaches,” he said.

——————————————————————————–

Sandia National Laboratories is a multi-program laboratory operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin company, for the U.S. Department of Energy’s National Nuclear Security Administration. With main facilities in Albuquerque, N.M., and Livermore, Calif., Sandia has major R&D responsibilities in national security, energy and environmental technologies and economic competitiveness.

Sandia news media contact: Neal Singer, nsinger@sandia.gov, 505-845-7078.

Dmitri May 25, 2013 at 13:41

Bion-M returned to Earth. This is the biggest biological space experiment done in recent time. NASA and DLR (German Space Agency) were in the core team. There are mixed reaction on results due to deaths of participants. In space you live as far as your automated life support is functioning. It fails – you die. End of story. Reliability is the key.

The scientists assure deaths of fishes, sand mice and most of rats is part of the experiment and in these wide field experiment they predicted death rate up to 50%. As the species were under camera monitoring the deaths were know to the experiment team.

Death of a crew or crew member in space is a touchy subject. It’s clearly acknowledge one at least on the Russian side. Death or death related simulations are not included in Mars experiments knowingly. The very first experiment Russians conducted resulted in such a tension between the crew that whatever iota would have resulted into miming or killing the crew member. Psychological aspect and environmental stress lead into such situation. Roscosmos has very openly talked about what the crew might do during a death in long-haul space flight. There is no established protocol but to reduce quilt, tension and blame from the crew the body has to be “buried”. As each member of the crew has personal belongings, especially ready-made space suite it’s most probably he’ll be let loose within it in to the space. There is an international treaty obstacle as the treaty prohibits littering the space and all the waste must be recycled. So even as simple trip to Mars has to be with fully established recycle protocol and technology. Non-recyclable material must be stored.

Bion-M:
1) All 8 sand mice died most probably due to feeding machine malfunctioning. There is also hints that they died due to stress. The transition to lack of gravity might have caused the stress that lead to the deaths. The litter which were replaced before the start developed a stress situation and killed one of the members. There is no direct or indirect indication to the cause of death but between the lines and how the death is depicted technical malfunctioning might have been just additional stress factor. Sand mice tend to develop aggression in stress situation but the litter stick together very strongly. They were included to study how long one can survive w/o water. They can go on a month, just the food must be sufficiently damp.

2) 39 of 45 mice died. There weren’t just mice but genetically engineered lineage mice (know pedigree and known genetic sequence). If there would have been genetic mutation it would have been easily detectable. A genetically bred mouse is in a middle-class sedan price range.

3) Fishes (cichlids) in fishtank died. After 12 days the light malfunctioned, the algae in the tank ceased photosynthesis and the fish died due to lack of oxygen. Blow to DLR but you learn from your mistakes. They were very concerned about this before the start.

4) All geckos survived. Geckos don’t feel stress in space and they can attach at any surface despite gravitation. Scientists tested theory changes in astronauts physiology is due to lack of pressure on nerve endings in the muscle. Geckos ability to stick on surfaces are thanks to their ability to control the nerve endings on the pawns.

5) All snails (Helix Lucorum Linnaeus) survived. They were operated before the flight to test functioning of regeneration in space. Also thanks to snail’s very simple nerve system and the complexity it expresses close to ours the goal is to study on synapses level changes space affects on biological species. Especially how vestibular apparatus is affected. Snails are the only animal who possesses a ferment which dissolves paper into glucose they eat. Just make sure there is enough paper and they are happy. The first sign of space affect was snails didn’t make difference between up and down.

6) On the outer layer of Bion-M craft were attached artificial meteorites, basalt slates, with drilled holes and caves with microbial spores see how they survive in direct space environment. Also some experiments on cell crystal growth and biological degradation were performed.

The most important is that the data will be available and all the conclusions can be made despite the losses. A commision is assembled to study reasons why deaths occurred because the long goal is to survive.

The program was financed and made to happen only thanks to private sector financing. In Russia there is no KickStart.com or other public financing options. They don’t tell how the finances were accrued just 2 mln rubles ($64K) came from the state and the other 6 mln rubles ($192K) from the private institutions and persons.

NASA just praises the results as the specimen was made available 11 hours after landing. This unprecedented.

Here is a short retrospective – http://www.youtube.com/watch?v=VVeA_JkKH5w&t=1m14s

Dmitri May 25, 2013 at 14:47

This is nice. Russians are testing Mars landing right on fresh astronauts from the ISS. 3 days for recuperation and straight ahead to the Mars landing simulator.

http://space.io9.com/i-watched-the-nasa-tv-feed-of-the-soyuz-return-from-iss-509588413

Comments on this entry are closed.

{ 3 trackbacks }